PGT-mt Atlas
An open database of published embryo heteroplasmy values from preimplantation genetic testing for mitochondrial DNA variants (PGT-mt). Each value is linked to its source.
For patients
What heteroplasmy means, what PGT-mt can offer, and why a percentage in a test report is not a diagnosis.
PGT-mt fundamentals
A six-chapter course on mtDNA inheritance and the interpretation of PGT-mt results, for clinicians, embryologists and students.
For specialists
Interactive charts, a source-linked data table, and an explanation of the methods and limitations.
The scientific database
what is inside
The Atlas presents published heteroplasmy levels and explains how to interpret these values.
- 187
- embryo heteroplasmy values
- 40
- blastocysts in which a biopsy sample was compared with other parts of the same embryo (including the inner cell mass in 20)
- 30
- comparisons between embryo and tissue samples from 16 foetuses and children; the variant was not detected in either sample for 12 foetuses and children
- 22
- publications (21 with a DOI)
Sections of the Atlas
from biopsy to data
- Within individual embryos
Agreement in heteroplasmy levels between different parts of the same embryo
Observed data - Embryo, foetus and child
Heteroplasmy in embryo biopsies and prenatal or postnatal samples
Observed data - PGT-mt × PGT-A model
Scenarios for joint selection using PGT-mt and preimplantation genetic testing for aneuploidy (PGT-A), and sensitivity to model assumptions
Model calculation
Published values only
Every value in the Atlas is linked to its primary source. These sources also underpin the mathematical model.