Observed data
Table of values
All observations, with the provenance of every value. CSV downloads use English labels and notes; identifiers and numerical data are unchanged.
Current dataset version: 187 embryo heteroplasmy values. Initial frozen version 2026-10-10: 187 values. Changes since the initial version: Tofilo et al. 2026: embryo 6 values (ICM, remaining TE) and the fraction category of embryos 3 and 4 follow the published ESM 2 (curation/corrections.yaml). The median range for pathogenic blastocysts was recalculated. Stable record identifiers introduced (HL-, EC-, CL-); former row-based identifiers are kept as aliases. (see Methods).
Embryos (Between different embryos)
n = 187
| ID | mtDNA variant | Value | Source | DOI | PMID | Atlas source worksheet, row | Source location | Stage | Sample type | How the value was obtained |
|---|---|---|---|---|---|---|---|---|---|---|
| HL-heindryckx2014-001 | m.3243A>G | not detected | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 4 | Table 1; embryo / sample: 3 / 11 (identity within ND records unresolved) | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-002 | m.3243A>G | 40.3% | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 5 | Table 1; embryo / sample: 1 | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-003 | m.3243A>G | 28.2% | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 6 | Table 1; embryo / sample: 2 | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-004 | m.3243A>G | not detected | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 7 | Table 1; embryo / sample: 3 / 11 (identity within ND records unresolved) | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-005 | m.3243A>G | 15.3% | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 8 | Table 1; embryo / sample: 4 | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-006 | m.3243A>G | 62% | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 9 | Table 1; embryo / sample: 5 | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-007 | m.3243A>G | 11.4% | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 10 | Table 1; embryo / sample: 6 | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-008 | m.3243A>G | 27.8% | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 11 | Table 1; embryo / sample: 7 | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-009 | m.3243A>G | 8.4% | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 12 | Table 1; embryo / sample: 8 | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-010 | m.3243A>G | 12.3% | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 13 | Table 1; embryo / sample: 9 | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-heindryckx2014-011 | m.3243A>G | 11.3% | Heindryckx et al., 2014 | 10.1016/j.mito.2014.08.005 | 25159128 | 14 | Table 1; embryo / sample: 10 | Blastocyst | TE biopsy sample | Mean of several biopsy measurements |
| HL-hyslop2025-001 | m.3243A>G | not detected (limit of detection: 3%) | Hyslop et al., 2025 | 10.1056/NEJMoa2415539 | 40673696 | 15 | Table 1, PGT; Hyslop 2025, Table 1, footnote: below 3% | Developmental stage not specified | Blastomere(s) | Derivation not recorded |
| HL-hyslop2025-002 | m.3243A>G | not detected (limit of detection: 3%) | Hyslop et al., 2025 | 10.1056/NEJMoa2415539 | 40673696 | 16 | Table 1, PGT; Hyslop 2025, Table 1, footnote: below 3% | Developmental stage not specified | Blastomere(s) | Derivation not recorded |
| HL-monnot2011-001 | m.3243A>G | not detected (limit of detection: 2%) | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 17 | Table 3; Monnot 2011, Results, Analysis in Day 3 to Day 5 Embryos, p. 118; Table 3, footnote a: detection threshold: 2%; embryo / sample: patient 2 embryos 1–6 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-002 | m.3243A>G | not detected (limit of detection: 2%) | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 18 | Table 3; Monnot 2011, Results, Analysis in Day 3 to Day 5 Embryos, p. 118; Table 3, footnote a: detection threshold: 2%; embryo / sample: patient 2 embryos 1–6 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-003 | m.3243A>G | not detected (limit of detection: 2%) | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 19 | Table 3; Monnot 2011, Results, Analysis in Day 3 to Day 5 Embryos, p. 118; Table 3, footnote a: detection threshold: 2%; embryo / sample: patient 2 embryos 1–6 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-004 | m.3243A>G | not detected (limit of detection: 2%) | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 20 | Table 3; Monnot 2011, Results, Analysis in Day 3 to Day 5 Embryos, p. 118; Table 3, footnote a: detection threshold: 2%; embryo / sample: patient 2 embryos 1–6 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-005 | m.3243A>G | not detected (limit of detection: 2%) | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 21 | Table 3; Monnot 2011, Results, Analysis in Day 3 to Day 5 Embryos, p. 118; Table 3, footnote a: detection threshold: 2%; embryo / sample: patient 2 embryos 1–6 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-006 | m.3243A>G | not detected (limit of detection: 2%) | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 22 | Table 3; Monnot 2011, Results, Analysis in Day 3 to Day 5 Embryos, p. 118; Table 3, footnote a: detection threshold: 2%; embryo / sample: patient 2 embryos 1–6 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-spath2021-001 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 23 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Half embryo | Mean of two embryo halves |
| HL-spath2021-002 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 24 | Supplemental Table 3; p. 1526, Results of Clinical Application; Spath 2021, Results of Clinical Application, p. 1526, Results of Clinical Application; Supplemental Table 3; Supplemental Table 3 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-003 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 25 | Supplemental Table 3; p. 1526, Results of Clinical Application; Spath 2021, Results of Clinical Application, p. 1526, Results of Clinical Application; Supplemental Table 3; Supplemental Table 3 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-004 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 26 | Supplemental Table 3; p. 1526, Results of Clinical Application; Spath 2021, Results of Clinical Application, p. 1526, Results of Clinical Application; Supplemental Table 3; Supplemental Table 3 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-005 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 27 | Supplemental Table 3; p. 1526, Results of Clinical Application; Spath 2021, Results of Clinical Application, p. 1526, Results of Clinical Application; Supplemental Table 3; Supplemental Table 3 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-006 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 28 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Half embryo | Mean of two embryo halves |
| HL-spath2021-007 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 29 | Supplemental Table 3; p. 1526, Results of Clinical Application; Spath 2021, Results of Clinical Application, p. 1526, Results of Clinical Application; Supplemental Table 3; Supplemental Table 3 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-008 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 30 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Half embryo | Mean of two embryo halves |
| HL-spath2021-009 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 31 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Half embryo | Mean of two embryo halves |
| HL-spath2021-010 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 32 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Half embryo | Mean of two embryo halves |
| HL-spath2021-011 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 33 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Whole embryo | Derivation not recorded |
| HL-spath2021-012 | m.3243A>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 34 | Supplemental Table 3; p. 1526, Results of Clinical Application; Spath 2021, Results of Clinical Application, p. 1526, Results of Clinical Application; Supplemental Table 3; Supplemental Table 3 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-013 | m.3243A>G | 3.1% | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 35 | Supplemental Table 3; p. 1526, Results of Clinical Application; Spath 2021, Results of Clinical Application, p. 1526, Results of Clinical Application; Supplemental Table 3; Supplemental Table 3; embryo / sample: D9 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-monnot2011-007 | m.3243A>G | 5% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 36 | Table 3; embryo / sample: patient 2 embryo 7 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-spath2021-014 | m.3243A>G | 5.7% | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 37 | Supplemental Table 3; p. 1526, Results of Clinical Application; embryo / sample: D19 (mean halves 4.6/6.8) | Developmental stage not specified | Half embryo | Mean of two embryo halves |
| HL-treff2012-001 | m.3243A>G | 7% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 38 | Table 1; embryo / sample: cleavage sample 1 | Cleavage stage | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-008 | m.3243A>G | 7.5% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 39 | Table 3; embryo / sample: patient 2 embryo 8 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-spath2021-015 | m.3243A>G | 11.5% | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 40 | Supplemental Table 3; p. 1526, Results of Clinical Application; Spath 2021, Results of Clinical Application, p. 1526, Results of Clinical Application; Supplemental Table 3; Supplemental Table 3; embryo / sample: D3 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-treff2012-002 | m.3243A>G | 12% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 41 | Table 1; embryo / sample: blastocyst sample 8 | Blastocyst | Multiple TE and ICM biopsy samples (mean) | Derivation not recorded |
| HL-monnot2011-009 | m.3243A>G | 13% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 42 | Table 3; embryo / sample: patient 2 embryo 9 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-010 | m.3243A>G | 14% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 43 | Table 3; Monnot 2011, Table 3, patient 2, embryo 10: blastomeres 13/13%, TE 15%; embryo / sample: patient 2 embryo 10 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Mean of blastomere and TE measurements |
| HL-monnot2011-011 | m.3243A>G | 14.5% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 44 | Table 3; embryo / sample: patient 2 embryo 11 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-012 | m.3243A>G | 15% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 45 | Table 3; embryo / sample: patient 2 embryo 12 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-013 | m.3243A>G | 16% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 46 | Table 3; embryo / sample: patient 2 embryo 13 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-014 | m.3243A>G | 18% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 48 | Table 3; embryo / sample: patient 1 embryo 1 | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-monnot2011-015 | m.3243A>G | 23% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 49 | Table 3; embryo / sample: patient 1 embryo 2 / patient 2 embryos 14–15 | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-monnot2011-016 | m.3243A>G | 23% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 50 | Table 3; embryo / sample: patient 1 embryo 2 / patient 2 embryos 14–15 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-017 | m.3243A>G | 23% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 51 | Table 3; embryo / sample: patient 1 embryo 2 / patient 2 embryos 14–15 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-treff2012-003 | m.3243A>G | 24% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 52 | Table 1; embryo / sample: blastocyst sample 1 | Blastocyst | Multiple TE and ICM biopsy samples (mean) | Derivation not recorded |
| HL-treff2012-004 | m.3243A>G | 24% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 53 | Table 1; embryo / sample: cleavage sample 6 | Cleavage stage | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-treff2012-005 | m.3243A>G | 25% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 54 | Table 1; embryo / sample: cleavage sample 5 | Cleavage stage | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-018 | m.3243A>G | 28% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 55 | Table 3; embryo / sample: patient 2 embryo 16 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-spath2021-016 | m.3243A>G | 29.2% | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 56 | Supplemental Table 3; p. 1526, Results of Clinical Application; Spath 2021, Results of Clinical Application, p. 1526, Results of Clinical Application; Supplemental Table 3; Supplemental Table 3; embryo / sample: D1 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-monnot2011-019 | m.3243A>G | 30% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 57 | Table 3; embryo / sample: patient 2 embryo 17 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-spath2021-017 | m.3243A>G | 36.3% | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 58 | Supplemental Table 3; p. 1526, Results of Clinical Application; embryo / sample: D2 (mean halves 37.0/35.6) | Developmental stage not specified | Half embryo | Mean of two embryo halves |
| HL-monnot2011-020 | m.3243A>G | 37% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 59 | Table 3; embryo / sample: patient 2 embryo 18 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-spath2021-018 | m.3243A>G | 37% | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 60 | Supplemental Table 3; p. 1526, Results of Clinical Application; embryo / sample: D8 (mean halves 37.1/36.9) | Developmental stage not specified | Half embryo | Mean of two embryo halves |
| HL-spath2021-019 | m.3243A>G | 38% | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 61 | Supplemental Table 3; p. 1526, Results of Clinical Application; embryo / sample: D17 (mean halves 39.6/36.4) | Developmental stage not specified | Half embryo | Mean of two embryo halves |
| HL-treff2012-006 | m.3243A>G | 38% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 62 | Table 1; embryo / sample: blastocyst sample 6 | Blastocyst | Multiple TE and ICM biopsy samples (mean) | Derivation not recorded |
| HL-monnot2011-021 | m.3243A>G | 42% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 63 | Table 3; embryo / sample: patient 2 embryos 19–20 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-022 | m.3243A>G | 42% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 64 | Table 3; embryo / sample: patient 2 embryos 19–20 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-023 | m.3243A>G | 43% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 65 | Table 3; embryo / sample: patient 2 embryo 21 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-024 | m.3243A>G | 47% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 66 | Table 3; embryo / sample: patient 2 embryo 22 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-025 | m.3243A>G | 48% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 67 | Table 3; embryo / sample: patient 2 embryo 23 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-026 | m.3243A>G | 50% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 68 | Table 3; embryo / sample: patient 1 embryo 3 / patient 2 embryos 24–27 | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-monnot2011-027 | m.3243A>G | 50% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 69 | Table 3; embryo / sample: patient 1 embryo 3 / patient 2 embryos 24–27 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-028 | m.3243A>G | 50% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 70 | Table 3; embryo / sample: patient 1 embryo 3 / patient 2 embryos 24–27 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-029 | m.3243A>G | 50% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 71 | Table 3; embryo / sample: patient 1 embryo 3 / patient 2 embryos 24–27 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-030 | m.3243A>G | 50% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 72 | Table 3; embryo / sample: patient 1 embryo 3 / patient 2 embryos 24–27 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-treff2012-007 | m.3243A>G | 52% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 73 | Table 1; embryo / sample: cleavage sample 4 | Cleavage stage | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-031 | m.3243A>G | 55% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 74 | Table 3; embryo / sample: patient 2 embryo 28 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-032 | m.3243A>G | 60% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 75 | Table 3; embryo / sample: patient 2 embryo 29 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-treff2012-008 | m.3243A>G | 61% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 76 | Table 1; embryo / sample: morula sample 1 | Morula | Whole embryo | Derivation not recorded |
| HL-monnot2011-033 | m.3243A>G | 62% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 77 | Table 3; embryo / sample: patient 2 embryo 30 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-034 | m.3243A>G | 63% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 78 | Table 3; embryo / sample: patient 2 embryo 31 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-035 | m.3243A>G | 66% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 79 | Table 3; embryo / sample: patient 2 embryo 32 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-treff2012-009 | m.3243A>G | 71% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 80 | Table 1; embryo / sample: cleavage sample 3 | Cleavage stage | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-036 | m.3243A>G | 74% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 81 | Table 3; embryo / sample: patient 2 embryo 33 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-treff2012-010 | m.3243A>G | 74% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 82 | Table 1; embryo / sample: blastocyst sample 7 | Blastocyst | Multiple TE and ICM biopsy samples (mean) | Derivation not recorded |
| HL-monnot2011-037 | m.3243A>G | 74.5% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 83 | Table 3; embryo / sample: patient 2 embryo 34 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-monnot2011-038 | m.3243A>G | 75% | Monnot et al., 2011 | 10.1002/humu.21417 | 21120938 | 84 | Table 3; embryo / sample: patient 2 embryo 35 | Developmental stage not specified | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-treff2012-011 | m.3243A>G | 81% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 85 | Table 1; embryo / sample: blastocyst sample 2 | Blastocyst | Multiple TE and ICM biopsy samples (mean) | Derivation not recorded |
| HL-treff2012-012 | m.3243A>G | 82% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 86 | Table 1; embryo / sample: blastocyst sample 5 | Blastocyst | Multiple TE and ICM biopsy samples (mean) | Derivation not recorded |
| HL-treff2012-013 | m.3243A>G | 86% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 87 | Table 1; embryo / sample: cleavage sample 2 | Cleavage stage | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-treff2012-014 | m.3243A>G | 89% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 88 | Table 1; embryo / sample: blastocyst sample 4 | Blastocyst | Multiple TE and ICM biopsy samples (mean) | Derivation not recorded |
| HL-treff2012-015 | m.3243A>G | 90% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 89 | Table 1; embryo / sample: blastocyst sample 3 | Blastocyst | Multiple TE and ICM biopsy samples (mean) | Derivation not recorded |
| HL-treff2012-016 | m.3243A>G | 91% | Treff et al., 2012 | 10.1016/j.fertnstert.2012.07.1119 | 22921075 | 90 | Table 1; embryo / sample: morula sample 2 | Morula | Whole embryo | Derivation not recorded |
| HL-ji2021-001 | m.3697G>A | 15.2% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 91 | Table 3; Ji 2021, Table 3, TE-biopsy column; embryo / sample: 2.11 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-002 | m.3697G>A | 23.5% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 92 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.10 | Arrested / degenerating embryo | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-ji2021-003 | m.3697G>A | 29.4% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 93 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.6 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-004 | m.3697G>A | 31.7% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 94 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.2 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-005 | m.3697G>A | 34.3% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 95 | Table 3; Ji 2021, Table 3, TE-biopsy column; embryo / sample: 2.4 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-006 | m.3697G>A | 36.48% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 96 | Table 3; Ji 2021, Table 3, sample 2.3 (1PN), six blastomeres; embryo / sample: 2.3 (mean of six blastomeres) | Arrested / degenerating embryo | Multiple blastomeres | Derivation not recorded |
| HL-ji2021-008 | m.3697G>A | 46.7% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 98 | Table 3; Ji 2021, Table 3, TE-biopsy column; embryo / sample: 2.6 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-009 | m.3697G>A | 47.3% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 99 | Table 3; Ji 2021, Table 3, TE-biopsy column; embryo / sample: 2.7 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-010 | m.3697G>A | 53.9% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 100 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 2.1 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-011 | m.3697G>A | 58.9% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 101 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.7 | Arrested / degenerating embryo | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-ji2021-012 | m.3697G>A | 67% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 102 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 2.2 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-013 | m.3697G>A | 70.9% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 103 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.1 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-014 | m.3697G>A | 85.3% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 104 | Table 3; Ji 2021, Table 3, TE-biopsy column; embryo / sample: 2.8 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-015 | m.3697G>A | 98.7% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 105 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.4 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-016 | m.3697G>A | 99% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 106 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.5 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-017 | m.3697G>A | 99.3% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 107 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.8 | Arrested / degenerating embryo | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-ji2021-018 | m.3697G>A | 99.4% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 108 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.11 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-019 | m.3697G>A | 99.7% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 109 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 1.3 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-020 | m.3697G>A | 100% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 110 | Table 3; Ji 2021, Table 3, TE-biopsy column; embryo / sample: 2.9 (six blastomeres) / 2.10 (TE); identity within equal values unresolved | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-ji2021-021 | m.3697G>A | 100% | Ji et al., 2021 | 10.1007/s10815-021-02354-3 | 34802141 | 111 | Table 3; Ji 2021, clinical case description pp. 3252–3253 and Table 3, one woman/two cycles; embryo / sample: 2.9 (six blastomeres) / 2.10 (TE); identity within equal values unresolved | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-sallevelt2017-001 | m.14487T>C | 5.75% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 112 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 1 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-002 | m.14487T>C | 8% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 113 | Fig. 2 / Supplementary Table SI; Sallevelt 2017, Fig. 2; Supplementary Table SI, cycle 2 embryo 13 (3PN); embryo / sample: cycle 2 embryo 13 (3PN) | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-tofilo2026-001 | m.14487T>C | 11.4% | Tofilo et al., 2026 | 10.1007/s10815-026-04012-y | 42649365 | 114 | ESM 2, Supplementary Table S2; Tofilo 2026, main text, clinical case and Results, six blastocysts from one carrier; embryo / sample: 1 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-tofilo2026-002 | m.14487T>C | 12% | Tofilo et al., 2026 | 10.1007/s10815-026-04012-y | 42649365 | 115 | ESM 2, Supplementary Table S2; Tofilo 2026, main text, clinical case and Results, six blastocysts from one carrier; embryo / sample: 3 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-sallevelt2017-003 | m.14487T>C | 12.25% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 116 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 7 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-tofilo2026-003 | m.14487T>C | 13.5% | Tofilo et al., 2026 | 10.1007/s10815-026-04012-y | 42649365 | 117 | ESM 2, Supplementary Table S2; Tofilo 2026, main text, clinical case and Results, six blastocysts from one carrier; embryo / sample: 6 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-sallevelt2017-004 | m.14487T>C | 21.1% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 118 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 9 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-005 | m.14487T>C | 21.4% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 119 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 11 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-006 | m.14487T>C | 43.6% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 120 | Fig. 2 / Supplementary Table SI; Sallevelt 2017, Fig. 2 / Supplementary Table SI; 3PN embryo (Atlas ID HL-sallevelt2017-006); embryo / sample: cycle 2 embryo 14 (3PN) | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-sallevelt2017-007 | m.14487T>C | 51.3% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 121 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 1 embryo 4 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-008 | m.14487T>C | 56.75% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 122 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 1 embryo 8 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-009 | m.14487T>C | 59.4% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 123 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 1 embryo 7 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-010 | m.14487T>C | 62.5% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 124 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 10 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-011 | m.14487T>C | 64.35% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 125 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 6 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-tofilo2026-004 | m.14487T>C | 73.2% | Tofilo et al., 2026 | 10.1007/s10815-026-04012-y | 42649365 | 126 | ESM 2, Supplementary Table S2; Tofilo 2026, main text, clinical case and Results, six blastocysts from one carrier; embryo / sample: 5 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-sallevelt2017-012 | m.14487T>C | 79.3% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 127 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 2 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-013 | m.14487T>C | 88.2% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 128 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 1 embryo 5 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-014 | m.14487T>C | 90.1% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 129 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 1 embryo 3 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-tofilo2026-005 | m.14487T>C | 92.3% | Tofilo et al., 2026 | 10.1007/s10815-026-04012-y | 42649365 | 130 | ESM 2, Supplementary Table S2; Tofilo 2026, main text, clinical case and Results, six blastocysts from one carrier; embryo / sample: 4 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-sallevelt2017-015 | m.14487T>C | 93.2% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 131 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 1 embryo 6 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-016 | m.14487T>C | 95.45% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 132 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 1 embryo 2 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-017 | m.14487T>C | 96.4% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 133 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 4 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-018 | m.14487T>C | 96.45% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 134 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 3 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-019 | m.14487T>C | 97.7% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 135 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 1 embryo 1 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-020 | m.14487T>C | 98.35% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 136 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 5 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-sallevelt2017-021 | m.14487T>C | 98.4% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 137 | Fig. 2 / Supplementary Table SI; embryo / sample: cycle 2 embryo 8 | Cleavage stage | Single blastomeres | Mean of two blastomeres |
| HL-tofilo2026-006 | m.14487T>C | 99.6% | Tofilo et al., 2026 | 10.1007/s10815-026-04012-y | 42649365 | 138 | ESM 2, Supplementary Table S2; Tofilo 2026, main text, clinical case and Results, six blastocysts from one carrier; embryo / sample: 2 | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-sallevelt2017-022 | m.14487T>C | 100% | Sallevelt et al., 2017 | 10.1093/humrep/dew356 | 28122886 | 139 | Fig. 2 / Supplementary Table SI; Sallevelt 2017, Fig. 2 / Supplementary Table SI; 3PN embryo (Atlas ID HL-sallevelt2017-022); embryo / sample: cycle 2 embryo 12 (3PN) | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-mizuguchi2025-001 | m.10197G>A | 1% | Mizuguchi et al., 2025 | 10.1038/s41439-025-00311-5 | 40164591 | 140 | Fig. 2A | Blastocyst | TE biopsy sample | Value digitised from a published figure |
| HL-mizuguchi2025-002 | m.10197G>A | 2% | Mizuguchi et al., 2025 | 10.1038/s41439-025-00311-5 | 40164591 | 141 | Fig. 2A | Blastocyst | TE biopsy sample | Value digitised from a published figure |
| HL-mizuguchi2025-003 | m.10197G>A | 2% | Mizuguchi et al., 2025 | 10.1038/s41439-025-00311-5 | 40164591 | 142 | Fig. 2A | Blastocyst | TE biopsy sample | Value digitised from a published figure |
| HL-mizuguchi2025-004 | m.10197G>A | 5% | Mizuguchi et al., 2025 | 10.1038/s41439-025-00311-5 | 40164591 | 143 | Fig. 2A | Blastocyst | TE biopsy sample | Value digitised from a published figure |
| HL-mizuguchi2025-005 | m.10197G>A | 5% | Mizuguchi et al., 2025 | 10.1038/s41439-025-00311-5 | 40164591 | 144 | Fig. 2A | Blastocyst | TE biopsy sample | Value digitised from a published figure |
| HL-mizuguchi2025-006 | m.10197G>A | published interval only: 26–45% | Mizuguchi et al., 2025 | 10.1038/s41439-025-00311-5 | 40164591 | 145 | Fig. 2A | Blastocyst | TE biopsy sample | Value digitised from a published figure |
| HL-mizuguchi2025-007 | m.10197G>A | published interval only: 84–88% | Mizuguchi et al., 2025 | 10.1038/s41439-025-00311-5 | 40164591 | 146 | Fig. 2A | Blastocyst | TE biopsy sample | Value digitised from a published figure |
| HL-mizuguchi2025-008 | m.10197G>A | 96% | Mizuguchi et al., 2025 | 10.1038/s41439-025-00311-5 | 40164591 | 147 | Fig. 2A | Blastocyst | TE biopsy sample | Value digitised from a published figure |
| HL-mizuguchi2025-009 | m.10197G>A | 96.5% | Mizuguchi et al., 2025 | 10.1038/s41439-025-00311-5 | 40164591 | 148 | Fig. 2A | Blastocyst | TE biopsy sample | Value digitised from a published figure |
| HL-spath2021-020 | m.10191T>C | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 149 | Supplemental Table 3; p. 1526, Results of Clinical Application | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-spath2021-021 | m.10191T>C | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 150 | Supplemental Table 3; p. 1526, Results of Clinical Application | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-spath2021-022 | m.10191T>C | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 151 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Whole embryo | Derivation not recorded |
| HL-spath2021-023 | m.10191T>C | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 152 | Supplemental Table 3; p. 1526, Results of Clinical Application | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-spath2021-024 | m.10191T>C | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 153 | Supplemental Table 3; p. 1526, Results of Clinical Application | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-spath2021-025 | m.10191T>C | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 154 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Whole embryo | Derivation not recorded |
| HL-spath2021-026 | m.10191T>C | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 155 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Whole embryo | Derivation not recorded |
| HL-spath2021-027 | m.10191T>C | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 156 | Supplemental Table 3; p. 1526, Results of Clinical Application | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-hyslop2025-004 | m.8993T>G | not detected (limit of detection: 3%) | Hyslop et al., 2025 | 10.1056/NEJMoa2415539 | 40673696 | 157 | Table 1, PGT; Hyslop 2025, Table 1, footnote: below 3% | Developmental stage not specified | Blastomere(s) | Derivation not recorded |
| HL-hyslop2025-005 | m.8993T>G | not detected (limit of detection: 3%) | Hyslop et al., 2025 | 10.1056/NEJMoa2415539 | 40673696 | 158 | Table 1, PGT; Hyslop 2025, Table 1, footnote: below 3% | Developmental stage not specified | Blastomere(s) | Derivation not recorded |
| HL-spath2021-028 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 159 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-029 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 160 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Whole embryo | Derivation not recorded |
| HL-spath2021-030 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 161 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-031 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 162 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-032 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 163 | Supplemental Table 3; p. 1526, Results of Clinical Application | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-spath2021-033 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 164 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-034 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 165 | Supplemental Table 3; p. 1526, Results of Clinical Application | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-spath2021-035 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 166 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Whole embryo | Derivation not recorded |
| HL-spath2021-036 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 167 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-037 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 168 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-038 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 169 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-039 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 170 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-040 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 171 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-041 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 172 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-042 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 173 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-043 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 174 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-044 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 175 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-045 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 176 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-spath2021-046 | m.8993T>G | not detected | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 177 | Supplemental Table 3; p. 1526, Results of Clinical Application | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-steffann2006-001 | m.8993T>G | not detected | Steffann et al., 2006 | 10.1136/jmg.2005.032326 | 16155197 | 178 | Table 1 / Fig. 1 | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-steffann2006-002 | m.8993T>G | not detected | Steffann et al., 2006 | 10.1136/jmg.2005.032326 | 16155197 | 179 | Table 1 / Fig. 1 | Cleavage stage | Multiple blastomeres | Derivation not recorded |
| HL-thorburn2009-001 | m.8993T>G | 2.5% | Thorburn et al., 2009 | — | — | 180 | Conference abstract; values via Castelluccio 2025 / Smeets 2023 (primary full text unavailable) | Cleavage stage | Blastomere(s) | Value obtained from reviews (primary source: abstract) |
| HL-spath2021-047 | m.8993T>G | 88.7% | Spath et al., 2021 | 10.1016/j.fertnstert.2021.01.026 | 33745725 | 181 | Supplemental Table 3; p. 1526, Results of Clinical Application | Developmental stage not specified | Whole embryo | Derivation not recorded |
| HL-steffann2006-003 | m.8993T>G | 94% | Steffann et al., 2006 | 10.1136/jmg.2005.032326 | 16155197 | 182 | Table 1 / Fig. 1 | Cleavage stage | Blastomeres and/or whole embryo (not specified) | Derivation not recorded |
| HL-hu2026-001 | m.3250T>C | 17.8% | Hu et al., 2026 | 10.1007/s10815-026-04041-7 | 42821212 | 183 | Supplementary Table S1; Hu 2026, clinical case description and embryo-results table, single carrier | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-hu2026-002 | m.3250T>C | not detected (limit of detection: 1%) | Hu et al., 2026 | 10.1007/s10815-026-04041-7 | 42821212 | 184 | Supplementary Table S1; Hu 2026, clinical case description and embryo-results table, single carrier | Arrested / degenerating embryo | Whole embryo | Derivation not recorded |
| HL-hu2026-003 | m.3250T>C | not detected (limit of detection: 1%) | Hu et al., 2026 | 10.1007/s10815-026-04041-7 | 42821212 | 185 | Supplementary Table S1; Hu 2026, clinical case description and embryo-results table, single carrier | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-hu2026-004 | m.3250T>C | not detected (limit of detection: 1%) | Hu et al., 2026 | 10.1007/s10815-026-04041-7 | 42821212 | 186 | Supplementary Table S1; Hu 2026, clinical case description and embryo-results table, single carrier | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-hu2026-005 | m.3250T>C | not detected (limit of detection: 1%) | Hu et al., 2026 | 10.1007/s10815-026-04041-7 | 42821212 | 187 | Supplementary Table S1; Hu 2026, clinical case description and embryo-results table, single carrier | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-hu2026-006 | m.3250T>C | 1.8% | Hu et al., 2026 | 10.1007/s10815-026-04041-7 | 42821212 | 188 | Supplementary Table S1; Hu 2026, clinical case description and embryo-results table, single carrier | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-hu2026-007 | m.3250T>C | not detected (limit of detection: 1%) | Hu et al., 2026 | 10.1007/s10815-026-04041-7 | 42821212 | 189 | Supplementary Table S1; Hu 2026, clinical case description and embryo-results table, single carrier | Arrested / degenerating embryo | Whole embryo | Derivation not recorded |
| HL-hu2026-008 | m.3250T>C | 8.1% | Hu et al., 2026 | 10.1007/s10815-026-04041-7 | 42821212 | 190 | Supplementary Table S1; Hu 2026, clinical case description and embryo-results table, single carrier | Blastocyst | TE biopsy sample | Derivation not recorded |
| HL-hyslop2025-006 | m.3243A>G | 9% | Hyslop et al., 2025 | 10.1056/NEJMoa2415539 | 40673696 | 47 | Table 1, PGT; Hyslop 2025, Table 1, m.3243A>G row: 9 and 24; footnote ‖ | Developmental stage not specified | Blastomere(s) | Derivation not recorded |
| HL-hyslop2025-007 | m.3243A>G | 24% | Hyslop et al., 2025 | 10.1056/NEJMoa2415539 | 40673696 | 47 | Table 1, PGT; Hyslop 2025, Table 1, m.3243A>G row: 9 and 24; footnote ‖ | Developmental stage not specified | Blastomere(s) | Derivation not recorded |